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2.\u5728\u6cbb\u7597\u5242\u91cf\u8303\u56f4\u5185\uff0c\u963f\u6208\u7f8e\u62c9\u6c40\u7684\u7cfb\u7edf\u66b4\u9732\u968f\u5242\u91cf\u5347\u9ad8\u800c\u6210\u6bd4\u4f8b\u5730\u589e\u52a0\u3002\u9ad8\u5242\u91cf\u65f6\uff0c\u9996\u8fc7\u6548\u5e94\u8fbe\u5230\u9971\u548c\u3002\u8fdb\u98df\uff08\u6807\u51c6\u996e\u98df\u6216\u9ad8\u8102\u996e\u98df\uff09\u4e0d\u5f71\u54cd\u963f\u6208\u7f8e\u62c9\u6c40\u7684\u751f\u7269\u5229\u7528\u5ea6\u6216\u5438\u6536\u7387\u3002\u9ad8\u8102\u996e\u98df\u4f1a\u589e\u52a0\u4e2a\u4f53\u5dee\u5f02\u3002<\/p>\n \u8d2e\u85cf<\/p>\n \u5bc6\u5c01\uff0c\u9634\u51c9\uff0c\u5e72\u71e5\u4fdd\u5b58[3] \u3002<\/p>\n \u4ea7\u54c1\u7528\u9014<\/p>\n \u892a\u9ed1\u6fc0\u7d20\u7c7b\u836f<\/p>\n \u963f\u6208\u7f8e\u62c9\u6c40\u2014\u2014\u7cbe\u795e\u75be\u75c5\u7c7b\u53c8\u4e00\u4e2a\u201c\u91cd\u78c5\u70b8\u5f39\u201d\u7ea7\u7684\u836f\u7269\u3002<\/p>\n 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\u3002<\/p>\n \u4e34\u5e8a\u7597\u6548<\/p>\n \u591a\u9879\u4e34\u5e8a\u7814\u7a76\u8bc1\u5b9e\u963f\u6208\u7f8e\u62c9\u6c40\u5177\u6709\u660e\u663e\u7684\u6297\u6291\u90c1\u4f5c\u7528\uff0c\u4e14\u8d77\u6548\u8f83\u5feb\uff0c\u5bf9\u6291\u90c1\u4ee5\u53ca\u4f34\u968f\u7684\u7126\u8651\u75c7\u72b6\u5747\u6709\u8f83\u597d\u7684\u7597\u6548\u3002<\/p>\n 2002\u5e74Lov\u7b49\u8fdb\u884c\u7684\u4e00\u9879\u4e3a\u671f8\u5468\u7684\u56fd\u9645\u591a\u4e2d\u5fc3\u5b89\u6170\u5242\u5bf9\u7167\u7814\u7a76\uff0c\u6bd4\u8f83\u4e86\u56fa\u5b9a\u5242\u91cf\u963f\u6208\u7f8e\u62c9\u6c40\u4e0e\u5e15\u7f57\u897f\u6c40\u7684\u7597\u6548\u3002\u7b26\u5408\u7f8e\u56fd\u7cbe\u795e\u969c\u788d\u8bca\u65ad\u548c\u7edf\u8ba1\u624b\u518c\u7b2c\u56db\u7248(DSM-IV)\u6291\u90c1\u969c\u788d(MDD)\u8bca\u65ad\u6807\u51c6\u7684711\u4f8b\u60a3\u8005\u5165\u7ec4\u8be5\u7814\u7a76\uff0c\u60a3\u8005\u5e74\u9f8418--65\u5c81\u3002\u60a3\u8005\u5728\u4f7f\u7528\u5b89\u6170\u5242\uff0c\u5468\u540e(\u4ee5\u6392\u9664\u5feb\u901f\u5b89w\u5242\u8d77\u6548\u8005)\u5206\u522b\u63a5\u53d7\u963f\u6208\u7f8e\u62c9\u6c40\u4e00\u65e51\u30015\u621625mg,\u6216\u5e15\u7f57\u897f\u6c40\u4e00\u65e520mg\u6216\u7ee7\u7eed\u63a5\u53d7\u5b89\u6170\u5242\u6cbb\u7597\u3002\u8fd9\u4e9b\u60a3\u8005\u6cbb\u7597\u524d\u6c49\u5bc6\u987f\u6291\u90c1r_-\u8868(HAMD)\u8bc4\u5206\u548c\u8499\u54e5\u9a6c\u5229\u6291\u90c1\u91cf\u8868(MADRS)\u8bc4\u5206\u5206\u522b\u4e3a27.4\u548c31.5\u5206\uff0c\u7ec4\u95f4\u65e0\u663e\u8457\u5dee\u5f02\u3002\u6cbb\u75978\u5468\u540e\uff0c\u4e0e\u5b89\u6170\u5242\u7ec4\u76f8\u6bd4\uff0cHAMID\u53caMADRS\u7ec8\u672b\u5e73\u5747\u5206\u8bc4\u4ef7\u663e\u793a\uff0c\u963f\u6208\u7f8e\u62c9\u6c4025mg\u7ec4\u548c\u5e15\u7f57\u897f\u6c40\u7ec4\u5747\u5177\u6709\u663e\u8457\u7684\u6297\u6291\u90c1\u7597\u6548(P<0.05).\u5e76\u4e14\u963f\u6208\u7f8e\u62c9\u6c4025mg\u7ec4\u7684\u8d77\u6548\u65f6\u95f4\u8f83\u5b89\u6170\u5242\u7ec4\u65e9(P'=0.008)\uff0c\u670d\u836f\u7b2c\u5468\u4fbf\u53ef\u89c1\u7ec4\u95f4\u663e\u8457\u5dee\u5f02(P<0.05)\uff0c\u800c\u5e15\u7f57\u897f\u6c40\u7ec4\u76f4\u5230\u7b2c4\u5468\u624d\u89c2\u5bdf\u5230\u4e0e\u5b89\u6170\u5242\u7ec4\u7684\u5dee\u5f02\u3002<\/p>\n \u8be5\u7814\u7a76\u8fd8\u5bf9\u6291\u90c1\u4f34\u7126\u8651\u75c7\u72b6\u4f5c\u4e86\u8bc4\u4f30\uff0c\u4e0e\u5b89\u6170\u5242\u7ec4\u76f8\u6bd4\uff0c\u963f\u6208\u7f8e\u62c9\u6c4025mg\u7ec4\u548c\u5e15\u7f57\u897f\u6c40\u7ec4\u5747\u80fd\u660e\u663e\u964d\u4f4e\u6c49\u5bc6\u987f\u7126\u8651\u91cf\u8868(HAMA)\u5206\u503c(P<0.05)\uff0c\u63d0\u793a\u963f\u6208\u7f8e\u62c9\u6c40\u53ef\u80fd\u4e0e\u5e15\u7f57\u897f\u6c40\u7c7b\u4f3c\uff0c\u80fd\u6539\u5584MDD\u60a3\u8005\u4f34\u968f\u7684\u7126\u8651\u60c5\u7eea\u3002\u8be5\u7814\u7a76\u5bf9HAMD\u5206\u503c\u226525\u7684\u60a3\u8005\u8fdb\u884c\u518d\u5206\u6790\u663e\u793a\uff0c\u4e0e\u5b89\u6170\u5242\u7ec4\u76f8\u6bd4\uff0c\u963f\u6208\u7f8e\u62c9\u6c4025mg\u7ec4\u7597\u6548\u663e\u8457{P<0.05},\u800c\u5e15\u7f57\u897f\u6c40\u7ec4\u4e0e\u5b89\u6170\u5242\u7ec4\u76f8\u6bd4\u5e76\u65e0\u663e\u8457\u5dee\u5f02(P=0.09).\u63d0\u793a\u963f\u6208\u7f8e\u62c9\u6c40\u5bf9\u8f83\u4e3a\u4e25\u91cd\u7684MDD\u7684\u7597\u6548\u53ef\u80fd\u4f18\u4e8e\u5e15\u7f57\u897f\u6c40\u7b49SSRI.<\/p>\n 2005\u5e74Olie\u8fdb\u884c\u76842\u9879\u53cc\u76f2\u5b89\u6170\u5242\u5e73\u884c\u5bf9\u7167\u7814\u7a76\uff0cMDD\u60a3\u8005\u968f\u673a\u63a5\u53d7\u963f\u6208\u7f8e\u62c9\u6c40\u4e00\u65e525mg\u6216\u5b89\u6170\u5242\uff0c2\u5468\u540e\u75c5\u60c5\u6539\u5584\u4e0d\u660e\u663e\u8005\u5242\u91cf\u589e\u52a0\u81f3\u4e00\u65e550mg,\u4e3a\u671f6\u5468\uff0c\u7ed3\u679c\u8868\u660e\uff0c\u963f\u6208\u7f8e\u62c9\u6c40\u7597\u6548\u660e\u663e\u4f18\u4e8e\u5b89\u6170\u5242\uff0c\u836f\u7269\u5242\u91cf\u589e\u52a0\u81f3\u4e00\u65e550mg\u80052\u5468\u540e\u83b7\u5f97\u7c7b\u4f3c\u7597\u6548\uff0c\u5e76\u4e14\u8010\u53d7\u6027\u826f\u597d.<\/p>\n 2007\u5e74\u53e6\u4e00\u9879\u53cc\u76f2\u5b89\u6170\u5242\u5e73\u884c\u5bf9\u7167\u7814\u7a76\u4e5f\u83b7\u5f97\u4e86\u76f8\u4f3c\u7684\u7ed3\u679c\u3002\u8be5\u7814\u7a76\u5171\u7eb3\u5165238\u4f8b\u4e2d\u91cd\u5ea6MID\u60a3\u8005\uff0c\u606f\u8005\u968f\u673a\u63a5\u53d7\u963f\u6208\u7f8e\u62c9\u6c40(\u4e00\u65e525mg,\u665a\u4e0a\u670d\uff0c2\u5468\u540e\u82e5\u7597\u6548\u6b20\u4f73\u5219\u52a0\u91cf\u81f3\u4e00\u65e550m9)\u6216\u5b89\u6170\u5242\uff0c\u7597\u7a0b6\u5468\u3002\u8bc4\u5b9a\u6807\u51c6\u4e3aHAMD\uff0c\u4e34\u5e8a\u603b\u4f53\u5370\u8c61\u91cf\u8868\u6539\u5584\u9879\u76ee(CGI\u4e00I)\u548c\u4e34\u5e8a\u603b\u4f53\u5370\u8c61\u91cf\u8868\u4e25\u91cd\u7a0b\u5ea6\u9879\u76ee(CGI\u4e00S)\u8bc4\u5206\uff0c\u7ed3\u679c\u663e\u793a\uff0c\u963f\u6208\u7f8e\u62c9\u6c40\u7597\u6548\u663e\u8457\u4f18\u4e8e\u5b89\u6170\u5242\uff0c\u4ee5HAMD\u7ec8\u672b\u5206\u503c\u76f8\u6bd4\u8f83\uff0c\u963f\u6208\u7f8e\u62c9\u6c40\u7ec4\u4e0e\u5b89\u6170\u5242\u7ec4\u4e24\u7ec4\u5dee\u5f02\u4e3a3.44(P<0.001)\uff0cCGI\u4e00I\u53caCGI\u4e00s\u8bc4\u5206\u4e5f\u663e\u793a\uff0c\u963f\u6208\u7f8e\u62c9\u6c40\u7ec4\u4f18\u4e8e\u5b89\u6170\u5242\u7ec4(\u7ec4\u95f4\u5dee\u5f02\u5206\u522b\u4e3a4.45\u548c0.50,P\u503c\u5747\u4e3a0.006).\u4e24\u7ec4\u6709\u6548\u7387\u5206\u522b\u4e3a54.3%\u5bf935.5%(P<0.05);\u8d77\u6548\u65f6\u95f4\u963f\u6208\u7f8e\u62c9\u6c40\u7ec4\u4e5f\u65e9\u4e8e\u5b89\u6170\u5242\u7ec4(P=0.008).\u5bf9\u91cd\u5ea6\u6291\u90c1\u75c7\u60a3\u8005\u4e5f\u6709\u7c7b\u4f3c\u7ed3\u679c\u3002\u53e6\u5916\uff0cHAMD\u91cf\u8868\u7684\u60c5\u7eea\u4e0e\u7761\u7720\u9879\u8bc4\u5206\u4e5f\u663e\u793a\u963f\u6208\u7f8e\u62c9\u6c40\u7ec4\u4f18\u4e8e\u5b89\u6170\u5242\u7ec4\u3002\u963f\u6208\u7f8e\u62c9\u6c40\u8010\u53d7\u6027\u597d\uff0c\u4e24\u4e2a\u5242\u91cf\u7ec4\u5747\u663e\u793a\u4e0e\u5b89\u6170\u5242\u76f8\u4f3c\u7684\u5b89\u5168\u6027\u3002<\/p>\n Pjrek\u7b49\u8fdb\u884c\u7684\u4e00\u9879\u6807\u7b7e\u5f00\u653e\u6027\u7814\u7a76\u8bc1\u5b9e\uff0c\u963f\u6208\u7f8e\u62c9\u6c40\u5bf9\u5b63\u8282\u6027\u60c5\u611f\u969c\u788d\u4e5f\u6709\u6548\u3002\u7ed9\u4e8837\u4f8b\u6025\u6027\u6291\u90c1\u53d1\u4f5c\u7684\u5b63\u8282\u6027\u60c5\u611f\u969c\u788d\u60a3\u8005\u665a\u95f4\u670d\u7528\u963f\u6208\u7f8e\u62c9\u6c40\u4e00\u65e525mg\uff0c\u4e3a\u671f14\u5468\uff0c\u4ee5HAMD\u7b49\u7ea7\u91cf\u8868\u7ed3\u6784\u5f0f\u8bbf\u8c08\u6307\u5bfc(SIGH\u4e00SAD)\u3001CGI-S\u3001CGI-I\u3001Circscreen\u91cf\u8868(\u5bf9\u7761\u7720\u4ee5\u53ca\u751f\u7406\u8282\u5f8b\u7d0a\u4e71\u8fdb\u884c\u81ea\u8bc4\u7684\u91cf\u8868)\u53ca\u8f7b\u5ea6\u8e81\u72c2\u91cf\u8868\u8fdb\u884c\u8bc4\u5b9a\u3002\u7ed3\u679c\u663e\u793a\uff0c2\u5468\u540e\u60a3\u8005\u7684SIGH-SAD\u3001CGI-S,CGI-I\u8bc4\u5206\u5373\u663e\u8457\u4e0b\u964d(P<0.001);Circscreen\u8bc4\u5206\u5728\u6cbb\u7597\u8fc7\u7a0b\u4e2d\u4e5f\u83b7\u5f97\u663e\u8457\u6539\u5584(P<0.001)\uff0c\u8f7b\u5ea6\u8e81\u72c2\u91cf\u8868\u8bc4\u5206\u65e0\u660e\u663e\u53d8\u5316.\u6cbb\u759714\u546875.7%\u60a3\u8005\u8fbe\u4e34\u5e8a\u597d\u8f6c(SIGH\u4e00SAD\u8bc4\u5206\u4f4e\u4e8e50%\u7684\u57fa\u7840\u8bc4\u5206)\uff0c70.3%\u8fbe\u4e34\u5e8a\u75ca\u6108(SIGH\u4e00SAD\u8bc4\u5206\u4f4e\u4e8e8))\uff0c\u4ec5\u4ec51\u4f8b\u51fa\u73b0\u4e4f\u529b\u7684\u4e0d\u826f\u53cd\u5e94 \u3002<\/p>\n \u5bf9\u7761\u7720\u7684\u5f71\u54cd<\/p>\n \u892a\u9ed1\u7d20\u5bf9\u7761\u7720\u4ee5\u53ca\u751f\u7269\u5468\u671f\u8282\u5f8b\u6709\u8c03\u8282\u4f5c\u7528\uff0c\u963f\u6208\u7f8e\u62c9\u6c40\u662f\u5426\u4e5f\u6709\u7c7b\u4f3c\u7684\u4f5c\u7528\u5f15\u8d77\u4eba\u4eec\u7684\u5173\u6ce8\uff0c\u5c24\u5176\u662f\u5f88\u591a\u6291\u90c1\u75c7\u60a3\u8005\u5747\u5b58\u5728\u7761\u7720\u969c\u788d\u3002\u52a8\u7269\u8bd5\u9a8c\u5df2\u8bc1\u5b9e\u963f\u6208\u7f8e\u62c9\u6c40\u5177\u6709\u4e0e\u892a\u9ed1\u7d20\u7c7b\u4f3c\u7684\u8c03\u8282\u7761\u7720\u7684\u4f5c\u7528\u3002\u4e00\u9879\u9488\u5bf9\u95e8\u8bcaMDD\u60a3\u8005\u7684\u7814\u7a76\u6bd4\u8f83\u4e86\u963f\u6208\u7f8e\u62c9\u6c40\u4e00\u65e525--5Omg\u4e0e\u6587\u62c9\u6cd5\u8f9b\u4e00\u65e575\u4e0015Dmg\u7684\u7597\u6548\uff0c\u7ed3\u679c\u663e\u793a\uff0c\u4e24\u8005\u6cbb\u7597\u6291\u90c1\u7597\u6548\u7c7b\u4f3c\uff0c\u4f46\u963f\u6208\u7f8e\u62c9\u6c40\u5728Leeds\u7761\u7720\u8bc4\u4f30\u95ee\u5377(LSEQ)\u91cf\u8868\u76842\u9879\u8bc4\u5206(\u5165\u7761\u548c\u7761\u7720\u8d28\u91cf)\u4e0a\u8f83\u6587\u62c9\u6cd5\u8f9b\u6539\u5584\u660e\u663e\uff0c\u5e76\u4e14\u89c2\u5bdf\u53d1\u73b0\uff0c\u8fd9\u79cd\u5bf9\u7761\u7720\u7684\u6539\u5584\u4f5c\u7528\u5728\u7528\u836f1\u5468\u65f6\u5373\u663e\u73b0\uff0c\u4e14\u5bf9\u767d\u5929\u7684\u8b66\u89c9\u6027\u65e0\u5f71\u54cd\u3002<\/p>\n \u53e6\u4e00\u9879\u6807\u7b7e\u5f00\u653e\u6027\u7814\u7a76\u8bc4\u4f30\u4e86\u963f\u6208\u7f8e\u62c9\u6c40\u5bf9MDD\u60a3\u8005\u7761\u7720\u7ed3\u6784\u7684\u5f71\u54cd\u300215\u4f8bHAMD\u8bc4\u5206\u226520\u7684\u95e8\u8bcaMDD\u60a3\u8005\u670d\u7528\u963f\u6208\u7f8e\u62c9\u6c40\u4e00\u65e525mg,\u4e3a\u671f42\u65e5\uff0c\u5728\u7b2c7,14,42\u65e5\u5206\u522b\u8fdb\u884c\u7761\u7720\u591a\u5bfc\u7814\u7a76\u3002\u7ed3\u679c\u663e\u793a\uff0c\u6cbb\u759742\u65e5\u60a3\u8005\u7684\u7761\u7720\u6548\u7387\u3001\u7761\u540e\u9192\u8f6c\u6b21\u6570\u53caSW5\u603b\u91cf\u5747\u6709\u6539\u5584\uff0cSWS\u5728\u5f00\u59cb\u7684\u90a3\u4e2a\u7761\u7720\u5468\u671f\u6539\u5584\u5c24\u4e3a\u663e\u8457\u3002\u4ece\u7b2c7\u65e5\u8d77\uff0cSWS\u5728\u6700\u5f00\u59cb\u76844\u4e2a\u7761\u7720\u5faa\u73af\u4e2d\u51cf\u5c11\uff0c\u572814\u65e5\u4ee5\u524d\uff0c\u03b4\u6ce2\u7684\u6bd4\u4f8b\u589e\u52a0\u3002REM\u6f5c\u4f0f\u671f\u3001\u603b\u91cf\u53ca\u5bc6\u5ea6\u5747\u672a\u89c1\u6539\u53d8\u3002\u63d0\u793a\u963f\u6208\u7f8e\u62c9\u6c40\u589e\u52a0\u7761\u7720\u7684\u8fde\u7eed\u6027\u4e0e\u8d28\u91cf\uff0c\u4f7f\u5728\u7761\u7720\u5468\u671f\u5faa\u73af\u4e2d\u7684\u5206\u914d\u53ca6\u6ce2\u7684\u5f3a\u5ea6\u6b63\u5e38\u5316\u3002<\/p>\n \u5b89\u5168\u6027\u4e0e\u8010\u53d7\u6027<\/p>\n \u963f\u6208\u7f8e\u62c9\u6c40\u4e0d\u826f\u53cd\u5e94\u8f83\u5c11\uff0c\u5e38\u89c1\u7684\u6709\u5934\u75db\u3001\u6076\u5fc3\u548c\u4e4f\u529b\u7b49.\u4e0d\u7ba1\u662f\u77ed\u671f\u6cbb\u7597\u8fd8\u662f\u957f\u671f\u7ef4\u6301\u6cbb\u7597\uff0c\u5176\u4e0d\u826f\u53cd\u5e94\u53d1\u751f\u7387\u4e0e\u5b89\u6170\u5242\u76f8\u4f3c\uff0c\u5e76\u4e14\u957f\u671f\u6cbb\u7597\u7684\u4e0d\u826f\u53cd\u5e94\u8f83\u77ed\u671f\u6cbb\u7597\u66f4\u5c11\u4e00\u4e9b\uff0c\u8fd9\u4e5f\u4e0e\u5b89\u6170\u5242\u76f8\u4f3c\u3002\u963f\u6208\u7f8e\u62c9\u6c40\u4e0d\u5f15\u8d77\u4f53\u91cd\u7684\u6539\u53d8\uff0c\u4e5f\u5f88\u5c11\u6709\u80c3\u80a0\u9053\u4e0d\u826f\u53cd\u5e94\uff0cLoo\u7b49\u540c\u8fdb\u884c\u7684\u4e34\u5e8a\u7814\u7a76\u663e\u793a\uff0c\u5e15\u7f57\u897f\u6c40\u7ec4\u6076\u5fc3\u53d1\u751f\u7387\u4e3a17%\uff0c\u5b89\u6170\u5242\u7ec4\u4e3a4.3%\uff0c\u800c\u963f\u6208\u7f8e\u62c9\u6c4025mg\u7ec4\u4ec5\u4e3a2.9%,\u7edf\u8ba1\u5b66\u68c0\u9a8c\u663e\u793a\u963f\u6208\u7f8e\u62c9\u6c40\u4e0e\u5b89\u6170\u5242\u7ec4\u76f8\u4f3c\uff0c\u800c\u4e0e\u5e15\u7f57\u897f\u6c40\u7ec4\u6709\u663e\u8457\u5dee\u5f02\u3002\u963f\u6208\u7f8e\u62c9\u6c40\u5bf9\u809d\u810f\u529f\u80fd\u3001\u80be\u810f\u529f\u80fd\u3001\u5fc3\u7535\u56fe\u7b49\u5747\u65e0\u5f71\u54cd\u3002<\/p>\n \u6297\u6291\u90c1\u836f\u7269\u5bf9\u6027\u529f\u80fd\u7684\u5f71\u54cd\u5df2\u5f15\u8d77\u76f8\u5f53\u7684\u91cd\u89c6\uff0cTCA\u3001SSRI\u3001\u9009\u62e9\u60275-HT\u53ca\u53bb\u7532\u80be\u4e0a\u817a\u7d20\u518d\u6444\u53d6\u6291\u5236\u5242(SNRI)\u7b49\u5747\u5b58\u5728\u5bf9\u6027\u529f\u80fd\u4e0d\u540c\u7a0b\u5ea6\u7684\u5f71\u54cd\uff0c\u4f46\u963f\u6208\u7f8e\u62c9\u6c40\u5bf9\u6027\u529f\u80fd\u7684\u5f71\u54cd\u8f83\u5c0f\u3002\u4e0e\u6587\u62c9\u6cd5\u8f9b\u76f8\u6bd4\uff0c\u963f\u6208\u7f8e\u62c9\u6c40\u7ec4\u6027\u529f\u80fd\u7684\u5404\u9879\u5fc3\u7406\u4e0e\u8eaf\u4f53\u75c7\u72b6\u8bc4\u5b9a\u5747\u4f18\u4e8e\u6587\u62c9\u6cd5\u8f9b\u3002<\/p>\n 2004\u5e74Montgomery\u7b49\u76ee\u8fdb\u884c7\u4e00\u9879\u6709\u5173\u64a4\u836f\u7684\u53cc\u76f2\u5b89\u6170\u5242\u5bf9\u7167\u7814\u7a76\uff0cMDD\u60a3\u8005\u5728\u53cc\u76f2\u6761\u4ef6\u4e0b\u63a5\u53d7\u963f\u6208\u7f8e\u62c9\u6c40\u4e00\u65e525mg\u6216\u5e15\u7f57\u897f\u6c40\u4e00\u65e520mg\u6cbb\u7597\uff0c\u7136\u540e192\u4f8b\u83b7\u5f97\u6301\u7eed\u7f13\u89e3\u7684\u60a3\u8005\u968f\u673a\u8fdb\u5165\u7ee7\u7eed\u6cbb\u7597\u7ec4\u6216\u5b89\u6170\u5242\u7ec4\uff0c\u4e3a\u671f2\u5468\uff0c\u5728\u7b2c1\u30012\u5468\u5206\u522b\u5bf9\u505c\u836f\u540e\u51fa\u73b0\u7684\u75c7\u72b6\u53ca\u4f53\u5f81\u91cf\u8868(DESS)\u8fdb\u884c\u8bc4\u5b9a\uff0c\u7ed3\u679c\u53d1\u73b0\uff0c\u7ee7\u7528\u963f\u6208\u7f8e\u62c9\u6c40\u548c\u505c\u7528\u963f\u6208\u7f8e\u62c9\u6c40\u7684\u4e24\u7ec4\u95f4DESS\u8bc4\u5206\u65e0\u663e\u8457\u5dee\u5f02\uff0c\u8868\u660e\u963f\u6208\u7f8e\u62c9\u6c40\u51e0\u65e0\u505c\u836f\u53cd\u5e94\uff0c\u800c\u5e15\u7f57\u897f\u6c40\u7ec4\u5728\u505c\u836f\u540e\u7b2c1\u5468\u5373\u51fa\u73b0\u660e\u663e\u7684\u5931\u7720\u3001\u5934\u6655\u3001\u6076\u5fc3\u548c\u808c\u75db\u7b49\u53cd\u5e94\uff0c\u8fd9\u4e9b\u53cd\u5e94\u5728\u7b2c2\u5468\u65f6\u6d88\u5931 .<\/p>\n \u7ed3\u8bba<\/p>\n \u963f\u6208\u7f8e\u62c9\u6c40\u4e3a\u9996\u4e2a\u892a\u9ed1\u7d20\u53d7\u4f53\u6fc0\u52a8\u5242\uff0c\u5177\u6709\u826f\u597d\u7684\u6297\u6291\u90c1\u6548\u679c\u3002\u5176\u8d77\u6548\u8f83\u5feb\uff0c\u5bf9\u6291\u90c1\u53ca\u5176\u4f34\u968f\u7684\u7126\u8651\u3001\u5931\u7720\u7b49\u75c7\u72b6\u5747\u6709\u8f83\u597d\u7684\u7597\u6548\uff0c\u4e14\u4e0d\u826f\u53cd\u5e94\u5c11\uff0c\u5b89\u5168\u6027\u9ad8\uff0c\u4e3a\u4e34\u5e8a\u6cbb\u7597MDD\u63d0\u4f9b\u4e86\u65b0\u65b9\u6cd5\u3002<\/p>\n \u82f1\u56fd\u6297\u6291\u90c1\u836f\u7814\u53d1\u73b0<\/p>\n \u636e\u82f1\u56fdABPI\u516c\u53f8\u6700\u65b0\u53d1\u8868\u7684\u4e00\u7bc7\u9898\u4e3a\u300a\u7784\u51c6\u6291\u90c1\u75c7\u300b\u7684\u62a5\u544a\u79f0\uff0c\u5bf9\u4e09\u4e2a\u795e\u7ecf\u9012\u8d28\u7cfb\u7edf\u540c\u65f6\u8d77\u4f5c\u7528\u7684\u6297\u6291\u90c1\u5242\u548c\u5177\u6709\u9644\u52a0\u53d7\u4f53\u6d3b\u6027\u76845-\u7f9f\u8272\u80fa\u518d\u6444\u53d6\u6291\u5236\u5242\uff0c\u53ea\u662f\u65b0\u6297\u6291\u90c1\u5242\u836f\u54c1\u4e2d\u7684\u4e00\u90e8\u5206\uff0c\u800c\u62a5\u544a\u4e2d\u4ecb\u7ecd\u7684\u53e6\u4e24\u4e2a\u5177\u201c\u4e09\u91cd\u4f5c\u7528\u201d\u5373\u963b\u65ad\u591a\u5df4\u80fa\u3001\u53bb\u7532\u80be\u4e0a\u817a\u7d20\u548c5-\u7f9f\u8272\u80fa\u7684\u91cd\u6444\u53d6\u7684\u5316\u5408\u7269\uff0c\u5206\u522b\u662fNeuroSearch\uff0c\u516c\u53f8\u5904\u4e8e\u2161\u671f\u4e34\u5e8a\u8bd5\u9a8c\u65e9\u671f\u7684NS2389\u548cOrganon\u516c\u53f8\u7684\u5904\u4e8e\u4e34\u5e8a\u524d\u5f00\u53d1\u9636\u6bb5\u7684Ory-32782\uff0c\u4e24\u5316\u5408\u7269\u76ee\u524d\u88ab\u4eba\u4eec\u5bc4\u4e88\u76f8\u5f53\u671f\u671b\u3002<\/p>\n Merck KgaA\u516c\u53f8\u7684EMD68843\u662f\u4e00\u79cd\u7ed3\u5408\u4e86\u9009\u62e9\u60275-\u7f9f\u8272\u80fa\u518d\u6444\u53d6\u6291\u5236\u5242(SSRI)\u548c\u5bf9\u5176\u5b83\u53d7\u4f53\u6d3b\u6027\u7684\u6297\u6291\u90c1\u5242\uff0c\u5177\u67095-\u7f9f\u8272\u80faTHT1A\u53d7\u4f53\u90e8\u5206\u6fc0\u52a8\u5242\u6d3b\u6027\uff0c\u662f\u4e00\u4e2a\u9009\u62e9\u60275-\u7f9f\u8272\u80fa\u518d\u6444\u53d6\u6291\u5236\u5242(SSRI)\u3002\u636e\u4fe1\u8fd9\u662f\u552f\u4e00\u7684\u7ed3\u5408\u4e86\u4e0a\u8ff0\u7279\u6027\u7684\u5316\u5408\u7269\uff0c\u5e76\u53ef\u80fd\u6709\u52a9\u4e8e\u63d0\u4f9b\u66f4\u591a\u76845-\u7f9f\u8272\u80fa\u6765\u523a\u6fc0\u8fd9\u4e9b\u4e0e\u6291\u90c1\u75c7\u6709\u5173\u7684\u53d7\u4f53\uff0c\u76ee\u524d\u6b63\u5904\u4e8e\u2162\u671f\/\u2162\u671f\u4e34\u5e8a\u8bd5\u9a8c(\u6700\u8fd1\u6709\u62a5\u9053\u65e5\u672c\u5c71\u4e4b\u5185\u516c\u53f8\u7684YM992\uff0c\u4e5f\u4e8e\u5904\u2161\u671f\u4e34\u5e8a\u8bd5\u9a8c\u9636\u6bb5\uff0c\u4f46\u5b83\u7ed3\u5408\u4e86SSRI\u6d3b\u6027\u548c\u5e76\u5177\u6709\u963b\u6ede5HT2A\u53d7\u4f53\u7684\u80fd\u529b)\u3002<\/p>\n \u81ea\u4eceMyeth\u516c\u53f8\u7684\u6587\u62c9\u6cd5\u8f9b\u57281995\u5e74\u6295\u653e\u5e02\u573a\u4ee5\u6765\uff0c\u8fd8\u6ca1\u6709\u5176\u5b83\u7eaf\u7cb9\u76845-\u7f9f\u8272\u80fa\u2014\u2014\u53bb\u7532\u80be\u4e0a\u817a\u7d20\u518d\u6444\u53d6\u6291\u5236\u5242\u9762\u5e02\u3002\u5176\u540e\u5c3d\u7ba1\u793c\u83b1\u516c\u53f8\u5df2\u7ecf\u5b8c\u6210\u4e86\u8be5\u7c7b\u5316\u5408\u7269\u5ea6\u6d1b\u897f\u6c40(duloxetine)\u7684\u6269\u5927\u7814\u7a76\uff0c\u4f46\u81f3\u4eca\u4ecd\u672a\u89c1\u51c6\u8bb8\u7528\u4e8e\u4e34\u5e8a\uff0c\u56e0\u6b64Orgnon\u516c\u53f8\u7684\u7c73\u6c2e\u5e73\u5c31\u6210\u4e86\u76ee\u524d\u5e02\u573a\u4e0a\u552f\u4e00\u4e00\u4e2a\u53ef\u4ee5\u4e70\u5230\u7684\u53bb\u7532\u80be\u4e0a\u817a\u7d20\u548c5-\u7f9f\u8272\u80fa\u9009\u62e9\u6027\u6297\u6291\u90c1\u5242(NaSSA)\u3002\u5176\u5b83\u63a2\u7d22\u53d7\u4f53\u4e9a\u578b\u7684\u516c\u53f8\u5305\u62ec\u963f\u65af\u7279\u62c9\u6377\u5229\u5eb7\uff0c\u6709\u62a5\u9053\u8be5\u516c\u53f8\u76ee\u524d\u6b63\u5728\u8bc4\u4f30\u4e00\u79cd\u9ad8\u9009\u62e9\u6027\u76845HT1A\u53d7\u4f53\u6291\u5236\u5242NAD299(\u6b63\u5904\u4e8e\u2161\u671f\u4e34\u5e8a\u8bd5\u9a8c)\u3002\u636e\u4fe1\uff0cNAD299\u5728\u6291\u90c1\u548c\u7126\u8651\u4e24\u65b9\u9762\u90fd\u6709\u5f00\u53d1\u7684\u6f5c\u529b\u3002Merck Sharp & 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